Direct contact
Harald Nitzschke +49 (0) 7303 - 92874 - 0 nitzschke@ttv-gmbh.de
In the pharmaceutical industry, it is not just active ingredients and formulations that determine the quality of a medicine. Stable production processes, hygiene safety and consistently reliable plant engineering are just as important. This is because even the slightest contamination, material changes or unplanned downtime can affect sensitive manufacturing processes, jeopardise batches or compromise validation. ttv supports pharmaceutical companies with application-specific solutions in the field of sealing and plain bearing technology for sensitive production environments. The focus is not only on individual components, but on the long-term stability and safety of the entire process.
See the customer reference: TEVA Pharmaceutical Industries/ratiopharm
Pharmaceutical production facilities place the highest demands on the components used. In addition to chemical resistance and hygienic safety, seals and plain bearings must be capable of withstanding repeated sterilisation, be resistant to process media, and operate reliably under process conditions. At the same time, the systems in use are subjected to aggressive cleaning agents, hot-steam sterilisation, significant temperature fluctuations, and varying pressure conditions. Design is therefore always tailored to the specific media, temperature and application, whilst taking regulatory requirements and hygiene standards into account.
The mechanical seals and O-rings used ensure the reliable sealing of sensitive pharmaceutical media, particularly in dynamic applications. The focus is on hygienic designs with high cleanability and minimal dead spaces. At the same time, the seals must withstand the stresses of cleaning and sterilisation processes over the long term. Depending on the application, special FDA-compliant elastomers, PTFE-based materials and high-purity carbon and ceramic mating surfaces are used.
Plain bearings also perform important functions in pharmaceutical plants. They are used in applications such as conveyor systems, packaging equipment, dosing systems, guides and rotating assemblies. Key requirements here include low friction coefficients, high resistance to media, reliable operation under demanding environmental conditions, and consistently reproducible running behaviour. Depending on the application, maintenance-free metal-polymer composite bearings, bronze plain bearings, PTFE-based materials or application-specific special solutions are used.
From the media used, through cleaning and sterilisation cycles, to regulatory requirements and real-world operating conditions, ttv regards sealing technology and bearing technology as an integral part of safe production processes.
This results in solutions that not only work technically, but also contribute to the long-term stability, safety and availability of pharmaceutical plants.
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Application
Sterile pump for handling sensitive pharmaceutical media within an automated filling line.
Requirements
High media resistance, reliable sterilisability and consistently leak-free processes under CIP and SIP conditions.
Solution
Use of a hygienic mechanical seal with FDA-compliant elastomers and chemically resistant material combinations.
Result
Reduced downtime, increased process reliability and consistently stable production conditions.
Application
Linear guides and bearing assemblies within a highly dynamic pharmaceutical packaging plant.
Requirements
Low-wear motion sequences, high resistance to cleaning and low-maintenance operation in cleanroom environments.
Solution
Use of maintenance-free PTFE-based plain bearings with high resistance to media and temperatures.
Result
Improved system availability, reduced maintenance requirements and reliable process stability during continuous operation.
Application
Sealing solutions for valve systems within an automated cleaning and sterilisation system.
Requirements
Resistance to aggressive cleaning agents, hot steam sterilisation and frequent temperature changes.
Solution
Use of specially designed O-rings made from materials compliant with FDA and USP Class VI standards.
Result
Longer service life, reduced maintenance intervals and safe cleaning processes under validated conditions.
